GLP-1 receptor (glp1r_human)
FAMILY
Class B1 (Secretin) Peptide receptors Glucagon receptor family GLP-1 receptor
GENE
GLP1R
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
G
|
A
|
P
|
G
|
P
|
L
|
R
|
L
|
10 |
A
|
L
|
L
|
L
|
L
|
G
|
M
|
V
|
G
|
R
|
20 |
A
|
G
|
P
|
R
|
P
|
Q
|
G
|
A
|
T
|
V
|
30 |
S
|
L
|
W
|
E
|
T
|
V
|
Q
|
K
|
W
|
R
|
40 |
E
|
Y
|
R
|
R
|
Q
|
C
|
Q
|
R
|
S
|
L
|
50 |
T
|
E
|
D
|
P
|
P
|
P
|
A
|
T
|
D
|
L
|
60 |
F
|
C
|
N
|
R
|
T
|
F
|
D
|
E
|
Y
|
A
|
70 |
C
|
W
|
P
|
D
|
G
|
E
|
P
|
G
|
S
|
F
|
80 |
V
|
N
|
V
|
S
|
C
|
P
|
W
|
Y
|
L
|
P
|
90 |
W
|
A
|
S
|
S
|
V
|
P
|
Q
|
G
|
H
|
V
|
100 |
Y
|
R
|
F
|
C
|
T
|
A
|
E
|
G
|
L
|
W
|
110 |
L
|
Q
|
K
|
D
|
N
|
S
|
S
|
L
|
P
|
W
|
120 |
R
|
D
|
L
|
S
|
E
|
C
|
E
|
E
|
S
|
K
|
130 |
TM1 | |||||||||
R
|
G
|
E
|
R
|
S
|
S
|
P
|
E
|
E
|
Q
|
140 |
L
|
L
|
F
|
L
|
Y
|
I
|
I
|
Y
|
T
|
V
|
150 |
G
|
Y
|
A
|
L
|
S
|
F
|
S
|
A
|
L
|
V
|
160 |
I
|
A
|
S
|
A
|
I
|
L
|
L
|
G
|
F
|
R
|
170 |
ICL1 | TM2 | ||||||||
H
|
L
|
H
|
C
|
T
|
R
|
N
|
Y
|
I
|
H
|
180 |
L
|
N
|
L
|
F
|
A
|
S
|
F
|
I
|
L
|
R
|
190 |
A
|
L
|
S
|
V
|
F
|
I
|
K
|
D
|
A
|
A
|
200 |
ECL1 | |||||||||
L
|
K
|
W
|
M
|
Y
|
S
|
T
|
A
|
A
|
Q
|
210 |
Q
|
H
|
Q
|
W
|
D
|
G
|
L
|
L
|
S
|
Y
|
220 |
TM3 | |||||||||
Q
|
D
|
S
|
L
|
S
|
C
|
R
|
L
|
V
|
F
|
230 |
L
|
L
|
M
|
Q
|
Y
|
C
|
V
|
A
|
A
|
N
|
240 |
Y
|
Y
|
W
|
L
|
L
|
V
|
E
|
G
|
V
|
Y
|
250 |
L
|
Y
|
T
|
L
|
L
|
A
|
F
|
S
|
V
|
L
|
260 |
TM4 | |||||||||
S
|
E
|
Q
|
W
|
I
|
F
|
R
|
L
|
Y
|
V
|
270 |
S
|
I
|
G
|
W
|
G
|
V
|
P
|
L
|
L
|
F
|
280 |
V
|
V
|
P
|
W
|
G
|
I
|
V
|
K
|
Y
|
L
|
290 |
ECL2 | |||||||||
Y
|
E
|
D
|
E
|
G
|
C
|
W
|
T
|
R
|
N
|
300 |
TM5 | |||||||||
S
|
N
|
M
|
N
|
Y
|
W
|
L
|
I
|
I
|
R
|
310 |
L
|
P
|
I
|
L
|
F
|
A
|
I
|
G
|
V
|
N
|
320 |
F
|
L
|
I
|
F
|
V
|
R
|
V
|
I
|
C
|
I
|
330 |
V
|
V
|
S
|
K
|
L
|
K
|
A
|
N
|
L
|
M
|
340 |
TM6 | |||||||||
C
|
K
|
T
|
D
|
I
|
K
|
C
|
R
|
L
|
A
|
350 |
K
|
S
|
T
|
L
|
T
|
L
|
I
|
P
|
L
|
L
|
360 |
G
|
T
|
H
|
E
|
V
|
I
|
F
|
A
|
F
|
V
|
370 |
ECL3 | TM7 | ||||||||
M
|
D
|
E
|
H
|
A
|
R
|
G
|
T
|
L
|
R
|
380 |
F
|
I
|
K
|
L
|
F
|
T
|
E
|
L
|
S
|
F
|
390 |
T
|
S
|
F
|
Q
|
G
|
L
|
M
|
V
|
A
|
I
|
400 |
H8 | |||||||||
L
|
Y
|
C
|
F
|
V
|
N
|
N
|
E
|
V
|
Q
|
410 |
L
|
E
|
F
|
R
|
K
|
S
|
W
|
E
|
R
|
W
|
420 |
R
|
L
|
E
|
H
|
L
|
H
|
I
|
Q
|
R
|
D
|
430 |
C-term | |||||||||
S
|
S
|
M
|
K
|
P
|
L
|
K
|
C
|
P
|
T
|
440 |
S
|
S
|
L
|
S
|
S
|
G
|
A
|
T
|
A
|
G
|
450 |
S
|
S
|
M
|
Y
|
T
|
A
|
T
|
C
|
Q
|
A
|
460 |
S
|
C
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
glucagon-like peptide 1-(7-37), glucagon, glucagon-like peptide 1-(7-36) amide
STRUCTURE MODELS
STRUCTURES
Found 40 structure(s) - view all details on the Structures page
PDBs: 5VEX, 5VEW, 5NX2, 6B3J, 6KJV, 6KK1, 6KK7, 6ORV, 6LN2, 6VCB, 7C2E, 6X18, 6X19, 6X1A, 6XOX, 7LCI, 7LCJ, 7LCK, 7E14, 7DUQ, 7KI0, 7KI1, 7DUR, 7EVM, 7RTB, 7S1M, 7S3I, 7LLL, 7LLY, 7FIM, 7VBI, 7RG9, 7RGP, 7VBH, 7S15, 7X8R, 7X8S, 8JIP, 8JIR, 8JIS